By the end of 2020, the COVID-19 pandemic, which reportedly started in the December of 2019, has caused more than 82 million cases and 2 million death. Currently some countries have begun to vaccinate, but they also have been hampered by the new virus variation. Taiwan has just announced that it will start to lock the country for one month in January 2021 and prohibit foreigners from entering. Therefore, it is necessary to observe whether the pandemic will be worse than expected and more difficult to control. Compared with SARS in 2003, MERS in 2012, COVID-19 in 2019 by far has the largest impact. The World Health Organization (WHO) warns that the cycle of emerging large-scale infectious diseases has shortened, indicating that the frequency of large-scale fatal diseases in the world may be entering a "New Normal" stage in the future.